We are running on a multi-tenant shared cloud version of Epicor. When we try to email from the Epicor system, we get a security error “550 5.7.64 Relay Access Denied ATTR36” from the Epicor cloud server. We are using Office 365.
People outside our domain get the emails but no one internally receives the email except for the reject email which goes to the system admin’s email address.
At least a year ago, EMS and the Cloud Team were two separate departments. When we left single tenant, we moved from Epicor Managed Services to the Cloud Team.
If you throw the SMTP error message into Google, you will get a number of hits - most of them relating to the configuration of Exchange Online Protection (EOP). Consider the cause of the error - the Epicor SMTP server is sending an email from someone at your company to someone else at your company and yet the source of the email (the Epicor SMTP Server) does not match your Email Server. According to EOP, clearly someone is trying to impersonate one of your employees so the message is rejected.
From the Google posts, it looks like you will need to work with the Office 365 Folks to configure EOP to allow what you want.