MES Personalizations Break - CompileCustomScript Error

We are on 10.2.300.7. The MES stations run a couple of customizations that have been stable since the upgrade but that randomly break. When trying to initiate a save layout, the following error displays:

CompileCustomScript
Could not find a part of the path ‘C:\Users\MES27\AppData\Local\Temp\64\t2egbtxa.tmp’

These run off of RemoteApp off of a Windows Server 2012 terminal server farm. We have not had this issue before and there were no changes to our environment.

Are we able to configure which folder these personalizations are written to so we can ensure this folder isn’t being cleared?