I am thinking it might be just a little more involved that a checkbox in the app server configuration
The following errors occurred while attempting to load the app.
- No assembly found containing an OwinStartupAttribute.
- No assembly found containing a Startup or [AssemblyName].Startup class.
To disable OWIN startup discovery, add the appSetting owin:AutomaticAppStartup with a value of “false” in your web.config.
To specify the OWIN startup Assembly, Class, or Method, add the appSetting owin:AppStartup with the fully qualified startup class or configuration method name in your web.config.